TL;DR Growth factor therapy addresses both wrinkles and pigmentation simultaneously through collagen stimulation and melanin regulation, with clinical studies showing significant improvement in dual-concern patients [2] . Combination protocols like microneedling with tranexamic acid reduced pigmentation MASI scores from 9.11 to 5.21 while improving wrinkles over 12 weeks [2] . Chemical peels combined with microneedling deliver superior results compared to monotherapy, with en